The half life of diphenhydramine in adults is 7–12 hours, and In a world full of Grinches be a Griswold vintage Christmas shirt. This is how long it takes for the body to get rid of half the drug. Per the NHTSA (National Highway Traffic Safety Administration: Effects on Driving: The drug manufacturer states that patients should be warned about engaging in activities requiring mental alertness such as driving a car. Diphenhydramine has repeatedly been shown to severely impair tracking and reaction time performance in actual on-the-road driving tests. Single doses of 50 mg have been shown to cause significant impairment during a 90 km highway test (measuring vehicle following, constant speed and lateral position).
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Then there’s the In a world full of Grinches be a Griswold vintage Christmas shirt . For simplicity, lets say each tablet is going to be around 1cm long, and 0.5cm wide and deep. Your 500 tablets make 125 cubic centimetres if they are packed together tightly, but they aren’t going to sit in a neat rectangle once ingested, they’ll be all jumbled around. Although the stomach can indeed stretch to accommodate on average 1000 cubic centimetres, it needs to be triggered by appropriate hunger signals before it will do that comfortably. Taking in a large volume of something that your body isn’t treating as food will likely make the person vomit. If the person were to slow their intake, it wouldn’t help, because once they start to absorb toxic levels that will also make them nauseated, and likely to vomit up the rest